Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
oleh: Gergo Gogl, Kristina V. Tugaeva, Pascal Eberling, Camille Kostmann, Gilles Trave, Nikolai N. Sluchanko
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
14-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across the proteome.