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Anaphylaxis reactions are not uncommon in routine practice and involve multiple systems usually. Cardiovascular collapse is the severest form of reaction. We present a case of severe anaphylactic reaction with cardiovascular collapse without other systems involvement which had to treat with intravenous adrenaline for a prolonged duration (successfully). The case is presented because of the rarity of presentation (single system involvement) and requirement of prolonged use of adrenaline for more than 24 h.