Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
oleh: Andy K. M. Lam, Raimund Dutzler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.