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Squamous Cell Carcinoma (SCC) of the tongue is the most widely recognised malignant neoplasm, representing 25 to 50% of all oral malignancies. In recent years, brachytherapy has been used in management of neoplasms of the head and neck region. This clinical report illustrates a method of customised mould fabrication for a 48-year-old patient diagnosed with SCC of lateral border of tongue undergoing brachytherapy treatment and emphasises the responsibility of a maxillofacial prosthodontist in designing a non-invasive prosthesis which maintains the radiotherapy catheters in the required predetermined position as per the requirement of the radiologist.