RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
oleh: Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C. James
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
The mechanism by which RING E3-anchored ubiquitin chains are formed is not well understood. Here, the authors solve a crystal structure of the RING E3 enzyme TRIM21 trapped in the process of self-anchored chain elongation and provide biochemical and cellular insights into the mechanism of ubiquitin conjugation.