Case Report: Kaposiform hemangioendothelioma with PIK3CA mutation successfully treated with sirolimus
oleh: Zuopeng Wang, Hanlei Yan, Yangyang Ma, Wei Yao, Shan Zheng, Kai Li
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2023-05-01 |
Deskripsi
Kaposiform hemangioendothelioma (KHE) is an extremely rare, locally aggressive vascular neoplasm. The etiopathogenesis of KHE is still poorly understood. In the present study, we found a new mutation in KHE (c.685delA, p.Thr229fs). The KHE patient with the PIK3CA mutation showed complete regression after sirolimus treatment. We propose that the presence of the PIK3CA mutation in KHE may correlate with good response to sirolimus.