Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2
oleh: Yufeng Liu, Linzhou Wang, Yingjun Li, Baode Ma, Gen-Qiang Chen, Xumu Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | KeAi Communications Co. Ltd. 2022-08-01 |
Deskripsi
A highly efficient and enantioselective method for the asymmetric reductive amination of β-keto phosphine derivatives was disclosed, and the corresponding β-amino phosphine oxides could be obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 97% ee). Moreover, the reaction worked well on a gram scale, indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.