Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
oleh: Eduardo Gomez-Bañuelos, Yikai Yu, Jessica Li, Kevin S. Cashman, Merlin Paz, Maria Isabel Trejo-Zambrano, Regina Bugrovsky, Youliang Wang, Asiya Seema Chida, Cheryl A. Sherman-Baust, Dylan P. Ferris, Daniel W. Goldman, Erika Darrah, Michelle Petri, Iñaki Sanz, Felipe Andrade
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.