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We solve some higher-order boundary value problems by the optimal homotopy asymptotic method (OHAM). The proposed method is capable to handle a wide variety of linear and nonlinear problems effectively. The numerical results given by OHAM are compared with the exact solutions and the solutions obtained by Adomian decomposition (ADM), variational iteration (VIM), homotopy perturbation (HPM), and variational iteration decomposition method (VIDM). The results show that the proposed method is more effective and reliable.