Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates
oleh: Mara Tomassetti, Gabriele Lupidi, Pamela Piermattei, Federico V. Rossi, Samuele Lillini, Gianluca Bianchini, Andrea Aramini, Marco A. Ciufolini, Enrico Marcantoni
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-10-01 |
Deskripsi
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.