Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma
oleh: Nekisa Zakeri, Andrew Hall, Leo Swadling, Laura J. Pallett, Nathalie M. Schmidt, Mariana O. Diniz, Stephanie Kucykowicz, Oliver E. Amin, Amir Gander, Massimo Pinzani, Brian R. Davidson, Alberto Quaglia, Mala K. Maini
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated with an efficient anti-tumour immune response in hepatocellular carcinoma.