Systemic muscle wasting and coordinated tumour response drive tumourigenesis
oleh: Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets, Susumu Hirabayashi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-scavenging programme to drive tumourigenesis.