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Accompanied with the rapid progress of materials technology and tissue engineering science, the increasing number of materials of organic polymer structure, especially nano-materials were highlighted by researchers in the field of biomedicine. Caused by some certain kinds of features, their excellent biocompatibility and security secondary to material size, surface modification, new materials were playing unique roles in drug delivery system, controlled release unit, disease detection etc. It provides a novel approach to diseases therapy. The application of new materials regarding organic polymer to ophthalmic drug therapy were focused in the review.