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This article considers the basic principles of a rational antibacterial therapy. The authors give a more detailed data on randomized controlled studies of azitromicine application (macrolide group) in case of upper airways respiratory infections of children. The findings demonstrate the effectiveness and safety of the medication, which allows practitioners to safely apply it for the treatment of the said pathology among children.Key words: azitromicine, upper airways respiratory infections, tonsillitis, otitis, sinusitis, children.