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Pressurized metered dose inhalers (pMDIs) contain propellants with high Global Warming Potential. This paper compares six pMDI products from the Polish market in terms of their contribution to environmental burden by analyzing the release and residuals of greenhouse gases during use and disposal. The results show that these similar medical products have markedly different carbon footprint values (12-22.5 kg CO2e), which might be mitigated by certain measures involving technical and legal actions.