Antibody dynamics post-Comirnaty and CoronaVac vaccination in Malaysia
oleh: Cheng Siang Tan, Vaenessa Noni, Whilemena Upam Herman Ulok Melina, Ummi Syafiqah Abdorahman, Joseph Niler Bimbang, Natasya Marliana Abdul Malik, Mohammad Esa Hossen, Md Mizanur Rahman, Lela Su’ut, Asri Said, Claire Chen, Bego Sepop, Morni Abu Samat, John Chee Ming Chew, Dewi Mamora, Sian Kong Tan
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
Abstract Several vaccines have been fast-tracked through clinical trials to mitigate the progression of the SARS‑CoV‑2 pandemic. We analyzed sequential blood samples from 314 recipients of Comirnaty and CoronaVac in East Malaysia for the spike-binding IgG (IgG-S), nucleocapsid-binding IgG (IgG-N), spike-binding IgM (IgM-S) and serum vitamin D (VitD). A subset of samples was analyzed for the neutralizing antibodies (Ig-RBD). Results showed that IgG-S due to Comirnaty was significantly higher than CoronaVac. IgM-S was detected in 80.0% Comirnaty and 69.5% CoronaVac recipients, while IgG-N was detected in 58.1% CoronaVac but not in Comirnaty recipients. All IgG-S-positive vaccines possessed detectable Ig-RBD after the second dose but with a weak to moderate correlation. The serum VitD levels did not influence the antibody magnitude in both vaccines. In essence, SARS-CoV-2 vaccination is an IgG-S-dominant event, Comirnaty was more effective than CoronaVac in mounting IgG-S and Ig-RBD responses, independent of the patient’s VitD level.