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Eight novel pyridyl–oxazole carboxamides were evaluated against fungi and displayed good fungicidal activities against <i>Botrytis cinereal</i> and <i>Rhizoctonia solani</i>. Preliminary bioassay results indicated that at 100 mg/L, compounds <b>6a</b>–<b>6</b><b>e</b>, <b>6g</b> and <b>6h</b> exhibited 100% fungicidal activities against <i>Botrytis cinerea</i>, and the compound <b>6b</b> to <i>Rhizoctonia solani</i> at 100%. Then, the zebrafish embryo acute toxicity test was performed to assess the toxicity of <b>6b</b> and <b>6c</b>. A series of malformations appeared, when the zebrafish embryos were exposed to <b>6b</b> and <b>6c</b>, such as delayed yolk sac resorption, significant shortening of body length, pericardial edema, bending spine, lack of melanin, heart hemorrhage, head hemorrhage, delayed swim sac development, yolk malformation and head malformation. In addition, the acute toxicity of <b>6b</b> to zebrafish embryo is 4.878 mg/L, and <b>6c</b> is 6.257 mg/L.