Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
oleh: Tobias Raisch, Chung-Te Chang, Yevgen Levdansky, Sowndarya Muthukumar, Stefan Raunser, Eugene Valkov
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and RNA binding proteins in targeted deadenylation.