Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling
oleh: Maria C. Tanzer, Isabell Bludau, Che A. Stafford, Veit Hornung, Matthias Mann
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Tumor necrosis factor (TNF) has various effects on phosphorylation-mediated cellular signaling. Combining phosphoproteomics, subcellular localization analyses and kinase inhibitor assays, the authors provide systems level insights into TNF signaling and identify modulators of TNF-induced cell death.