Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium
oleh: Julie Joseph, Emmanuelle S. Ametepe, Naveen Haribabu, Gerard Agbayani, Lakshmi Krishnan, Alexandre Blais, Subash Sad
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
FoxO3a signalling has limited influence over acute bacterial infection. Here the authors show that FoxO3a promotes survival of mice in response to chronic Salmonellatyphimurium infection by restraining oxidative stress and ERK signalling.