Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization
oleh: Lijuan Zhang, Kai Zhang, Jieyou Zhang, Jinrong Zhu, Qing Xi, Huafeng Wang, Zimu Zhang, Yingnan Cheng, Guangze Yang, Hongkun Liu, Xiangdong Guo, Dongmei Zhou, Zhenyi Xue, Yan Li, Qi Zhang, Yurong Da, Li Liu, Zhinan Yin, Zhi Yao, Rongxin Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.