Comparison of Nitric Oxide Concentration in Seminal Fluid between Infertile Patients with and without Varicocele and Normal Fertile Men
oleh: Fateme Esfehani, Gholamhossein Naderi, Mohammadali Sedighi Gilani, Hossein Keyhan, Mohammad Ansari, Darab Mehraban
| Format: | Article |
|---|---|
| Diterbitkan: | Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2005-05-01 |
Deskripsi
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">Introduction</span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">: Elevated nitric oxide (NO) levels have been shown to have toxic effects on sperm function and motility. This study was conducted to compare NO levels in the seminal fluid of infertile men with varicocele with those of infertile and fertile men without varicocele.</span></span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">Materials and Methods: </span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">Semen samples were obtained from 40 infertile men with varicocele (group 1), 40 infertile men without varicocele (group 2), and 40 fertile volunteers without varicocele (group 3). NO levels in the seminal plasma of patients in each group were measured and compared. In infertile men with varicocele, semen parameters, including sperm count and motility, and grade of varicocele were also determined. <strong></strong></span></span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: justify;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">Results: </span></strong><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">Mean NO concentrations were 52.34 </span><span style="mso-bidi-language: FA;">± </span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">26.62 </span><span style="mso-bidi-language: FA;">µ</span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">mol/L, 37.06 </span><span style="mso-bidi-language: FA;">± </span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">20.39 </span><span style="mso-bidi-language: FA;">µ</span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">mol/L, and 33.7 </span><span style="mso-bidi-language: FA;">± </span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">18.99 </span><span style="mso-bidi-language: FA;">µ</span><span style="mso-bidi-language: FA; mso-bidi-font-family: 'B Yagut';">mol/L in groups 1, 2, 3, respectively. Concentrations in group 1 were significantly higher than were those in groups 2 and 3 (<em>P </em>= 0.001). In group 1, no significant correlations were seen between NO concentrations and grades of varicocele, sperm count, sperm motility, or ages of the patients.<span style="mso-spacerun: yes;"> </span><strong></strong></span></span></span></p><strong><span style="font-size: 12pt; font-family: ">Conclusion: </span></strong><span style="font-size: 12pt; font-family: ">Data from the current study suggest a </span><span style="font-size: 12pt; font-family: ">possible role of NO in damaging the sperm function in varicocele</span><span style="font-size: 12pt; font-family: "> as demonstrated by an increased concentration of NO in the seminal fluid of infertile men with varicocele compared with the seminal fluid of fertile and infertile men without varicocele</span><span style="font-size: 12pt; font-family: ">.</span>