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The cultivation of crops in the greenhouse is the most intensive form of horticultural production. Greenhouse climatic conditions provide an ideal condition for the development of many foliar, stem and soil-borne plant diseases. Diseases are a major limiting factor for vegetable that cause serious yield reduction leading to severe economic losses. Fungi enter plants through natural openings such as stomata and through wounds caused by pruning, harvesting, hail, insects, other diseases, and mechanical damage. This chapter provides an overview of the most important diseases of tomato plants. Some of the diseases that will cover in this chapter are the follow: Early blight late, Septoria leaf spot, Late blight, Fusarium wilt, Verticillium wilt, Anthracnose, Buckeye rot, and Southern blight. For each disease, main symptoms and disease development are described. This review is based on combined information derived from available literature and expertise knowledge. DOI: http://dx.doi.org/10.5281/zenodo.1011161