An integration-free iPSC line ZZUNEUi008-A derived from dermal fibroblasts of a child with cardiac valvular dysplasia carrying a mutation in FLNA gene
oleh: Xiaowei Li, Yanyu Lu, Jiaxiang Wang, Mengduan Liu, Mengyu Wang, Liang Hu, Wenting Du, Lu Wang, Zhengming Jiang, Xiangmei Gu, Zhongren Ding, Deguang Feng, Ling Li, Jianzeng Dong, Xiaoyan Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2020-08-01 |
Deskripsi
FLNA gene encodes an actin-binding protein filamin A and mutations in FLNA can causes X-Linked cardiac valvular dysplasia. In this study, we report the generation of ZZUNEUi008-A, a human induced pluripotent stem cell line from a 10-year-old male patient with c. 84G → A in FLNA gene using non-integrative Sendai viral reprogramming technology. The ZZUNEUi008-A iPSC line expresses pluripotency markers, exhibits a normal male karyotype (46, XY) and can differentiate into three germ layers in vivo.