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The most common anomaly in thyroid development is thyroglossal duct cyst which results from the failure of involution of the thyroglossal tract. Carcinoma arising from the thyroglossal duct is rare with fewer than 275 cases reported till date. Papillary carcinoma is the most common among them. Majority of patients are females within first two decades of life. Five year survival is less than 2%. We report a case in 27 year-old female who presented with painless, midline neck swelling which slowly progressed in size over one year. Histopathology revealed primary papillary carcinoma arising from the thyroglossal cyst.