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A facile microwave assisted one-pot synthesis of novel 1-methylhexahydroquinazolin-5(6H)-ones and bis-1-methylhexahydroquinazolin-5(6H)-ones
oleh: Madhusudhan Saha, Enamul Karim, Jai Narain Vishwakarma, Rishanlang Nongkhlaw
Format: | Article |
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Diterbitkan: | Universidade Federal de Mato Grosso do Sul 2011-03-01 |
Deskripsi
<div align="justify">Novel hexahydroquinazolin-5(6H)-ones 3a-j have been synthesized in good yields by the reaction of enaminones 2a-b with primary amines and formaldehyde under the influence microwaves. Enaminones 2a-b have also been reacted with diamines and formaldehyde under similar conditions resulting in hitherto unreported bis- hexahydroquinazolin-5(6H)-ones 4a-d and 5a-d. The structures of the molecules have been established with the help of spectral and analytical data.</div>