Target Molecular Simulations of RecA Family Protein Filaments

oleh: Yeng-Tseng Wang, Wen-Jay Lee, Wan-Sheng Su, Zhi-Yuan Su

Format: Article
Diterbitkan: MDPI AG 2012-06-01

Deskripsi

Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations. Inclusion of our simulations may help to understand the RadA family mechanism.