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Target Molecular Simulations of RecA Family Protein Filaments
oleh: Yeng-Tseng Wang, Wen-Jay Lee, Wan-Sheng Su, Zhi-Yuan Su
Format: | Article |
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Diterbitkan: | MDPI AG 2012-06-01 |
Deskripsi
Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations. Inclusion of our simulations may help to understand the RadA family mechanism.