CD44: a cancer stem cell marker and therapeutic target in leukemia treatment
oleh: Shuang Wu, Shuang Wu, Yicheng Tan, Yicheng Tan, Yicheng Tan, Fanfan Li, Fanfan Li, Fanfan Li, Yixiang Han, Yixiang Han, Yixiang Han, Shenghui Zhang, Shenghui Zhang, Shenghui Zhang, Shenghui Zhang, Xiaofei Lin
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2024-04-01 |
Deskripsi
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.