ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells
oleh: Lan Wang, Bei Mao, Keyang Fan, Renqiang Sun, Jialong Zhang, Huazheng Liang, Ying Liu
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-09-01 |
Deskripsi
Keypoints 1. The expression of tight junction protein ZO-1 decreased significantly in the aged human brain. 2. TET activity of cerebral endothelial cells declines during aging. 3. TET activity is essential in regulating the expression of ZO-1 by endothelial cells of BBB.