Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples

oleh: Anna Schueth, Sven Hildebrand, Iryna Samarska, Shubharthi Sengupta, Annemarie Kiessling, Andreas Herrler, Axel zur Hausen, Michael Capalbo, Alard Roebroeck

Format: Article
Diterbitkan: Nature Portfolio 2023-02-01

Deskripsi

A light-sheet microscopy prototype, the cleared-tissue dual view Selective Plane Illumination Microscope (ct-dSPIM), is presented and shown to enable quantitative assessment of large-scale human tissue samples in 3D with clinical potential.