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Growing evidence indicates the involvement of a genetic component in prostate cancer (CaP) susceptibility and clinical severity. Studies have reported the role of germline mutations and single nucleotide polymorphisms (SNPs) of <i>TP53</i> as possible risk factors for cancer development. In this single institutional retrospective study, we identified common SNPs in the <i>TP53</i> gene in AA and CA men and performed association analyses for functional <i>TP53</i> SNPs with the clinico-pathological features of CaP. The SNP genotyping analysis of the final cohort of 308 men (212 AA; 95 CA) identified 74 SNPs in the <i>TP53</i> region, with a minor allele frequency (MAF) of at least 1%. Two SNPs were non-synonymous in the exonic region of <i>TP53</i>: rs1800371 (Pro47Ser) and rs1042522 (Arg72Pro). The Pro47Ser variant had an MAF of 0.01 in AA but was not detected in CA. Arg72Pro was the most common SNP, with an MAF of 0.50 (0.41 in AA; 0.68 in CA). Arg72Pro was associated with a shorter time to biochemical recurrence (BCR) (<i>p</i> = 0.046; HR = 1.52). The study demonstrated ancestral differences in the allele frequencies of the <i>TP53</i> Arg72Pro and Pro47Ser SNPs, providing a valuable framework for evaluating CaP disparities among AA and CA men.