MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

oleh: Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter, Albert R. La Spada

Format: Article
Diterbitkan: Nature Portfolio 2018-03-01

Deskripsi

Amino acids stimulate cell growth and depletion in a cell activates autophagy, yet how this is regulated is unclear. Here, the authors show that MAP4K3 (also known as germinal-center kinase-like kinase) acts as an amino acid-dependent regulator of autophagy, via phosphorylation of the transcription factor EB.