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<p/> <p>In order to achieve seamless handover for real-time applications in the IP Multimedia Subsystem (IMS) of next generation network, a multiprotocol combined handover mechanism is proposed in this paper. We combine SIP (Session Initiation Protocol), FMIP (Fast Mobile IPv6 Protocol), and MIH (Media Independent Handover) protocols by cross-layer design and optimize those protocols' signaling flows to improve the performance of vertical handover. Theoretical analysis and simulation results illustrate that our proposed mechanism performs better than the original SIP and MIH combined handover mechanism in terms of service interruption time and packet loss.</p>