Validity of a Portable Breath Analyser (AIRE) for the Assessment of Lactose Malabsorption

oleh: Aahana Shrestha, Utpal K. Prodhan, Sarah M. Mitchell, Pankaja Sharma, Matthew P.G. Barnett, Amber M. Milan, David Cameron-Smith

Format: Article
Diterbitkan: MDPI AG 2019-07-01

Deskripsi

Hydrogen (H<sub>2</sub>) measurement in exhaled breath is a reliable and non-invasive method to diagnose carbohydrate malabsorption. Currently, breath H<sub>2</sub> measurement is typically limited to clinic-based equipment. A portable breath analyser (AIRE, FoodMarble Digestive Health Limited, Dublin, Ireland) is a personalised device marketed for the detection and self-management of food intolerances, including lactose malabsorption (LM). Currently, the validity of this device for breath H<sub>2</sub> analysis is unknown. Individuals self-reporting dairy intolerance (six males and six females) undertook a lactose challenge and a further seven individuals (all females) underwent a milk challenge. Breath samples were collected prior to and at frequent intervals post-challenge for up to 5 h with analysis using both the AIRE and a calibrated breath hydrogen analyser (BreathTracker, QuinTron Instrument Company Inc., Milwaukee, WI, USA). A significant positive correlation (<i>p</i> &lt; 0.001, r &gt; 0.8) was demonstrated between AIRE and BreathTracker H<sub>2</sub> values, after both lactose and milk challenges, although 26% of the AIRE readings demonstrated the maximum score of 10.0 AU. Based on our data, the cut-off value for LM diagnosis (25 ppm H<sub>2</sub>) using AIRE is 3.0 AU and it is effective for the identification of a response to lactose-containing foods in individuals experiencing LM, although its upper limit is only 81 ppm.