Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
oleh: Marina Vabistsevits, George Davey Smith, Eleanor Sanderson, Tom G. Richardson, Bethan Lloyd-Lewis, Rebecca C. Richmond
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Previous studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. A Mendelian randomization analysis suggests that the effects of adiposity may remain even when 18 potential mediators are accounted for, suggesting a lack of evidence for mediation and that other mediating pathways remain to be determined.