Stereoselective synthesis of a-hydroxy-b-amino acids: the chiral pool approach
oleh: RADOMIR N. SAICIC, RADOMIR MATOVIC, GORDANA TASIC
| Format: | Article |
|---|---|
| Diterbitkan: | Serbian Chemical Society 2004-11-01 |
Deskripsi
A method for the stereoselective homologation of a-amino acids into syn-a-hydroxy-b-amino acids is described, based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin.