Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV
oleh: Lúcio Roberto Castellano, Mauricio Llaguno, Marcos Vinícius Silva, Juliana Reis Machado, Dalmo Correia, Mario León Silva-Vergara, Virmondes Rodrigues
| Format: | Article |
|---|---|
| Diterbitkan: | Sociedade Brasileira de Medicina Tropical (SBMT) 2011-08-01 |
Deskripsi
HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.