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The article describes major etiological factors and mechanisms of rhinosinusitis, traditional approaches to therapy of rhinosinusitis in children. Special attention is given to mechanisms of intense antiseptic, antifungal and immune modulating action of silver. The article presents Protargol drug that can be prepared immediately before application. Due to the silver proteinate with antiseptic, anti-inflammatory and binding effects Protargol can be used for therapy of acute and chronic rhinosinusitis in children.