Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
oleh: Yan Kai, Jaclyn Andricovich, Zhouhao Zeng, Jun Zhu, Alexandros Tzatsos, Weiqun Peng
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
CTCF mediates long-range chromatin interactions which are important for genome organization and function. Here, the authors demonstrate that CTCF-mediated interactome exhibits extensive plasticity and present Lollipop, a machine-learning framework which predicts CTCF-mediated long-range interactions using genomic and epigenomic features.