Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
oleh: Momoko Watanabe, Kazunori Kurihara, Norio Miyaura, Yasunori Yamamoto, Tomohiko Shirai
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2011-06-01 |
Deskripsi
A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivities.