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Viral infections are common opportunistic infections in renal transplant recipients which can cause allograft dysfunction and are often a major cause of graft dysfunction in the South Asian region. Cytomegalovirus (CMV) and BK viral infections are often seen in the early and late posttransplant periods, respectively. Coinfection of both these viruses is rare and hence early diagnosis is the key to prevent graft loss. We present the cases of two male renal transplant recipients with CMV and BKV coinfection with diverse outcomes.