Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
oleh: Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. Sobolevsky
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.