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ICD implantation, such as other surgical procedures, was not free from complications, first of all infection’s development. This complication often induces partial or complete device extraction, followed by a re-implantation. Re-implantation timing is modulated depending on the resolution of the infection and presence or absence of a spontaneous cardiac rhythm. A 62 years old patient was treated with CIED implantation after a diagnosis of atrioventricular cardiac conduction alteration. Healthcare workers diagnosed a pocket infection about a month after implantation and performed a device complete extraction, without programming a re-implantation because of a pro-inflammatory state. He died from acute arrhythmia fourteen days after the device extraction. Recent guidelines deal with therapeutic approaches' disputes, indicating a two weeks waiting before the ICD re-implantation in case of infection, not providing any indication in patients with alteration of pro-inflammatory parameters. Further studies are awaited to deal with disputes of appropriate therapeutic approaches' timing and implement future guidelines.