Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins
oleh: Hang Zhang, Shan-Jun Zhang, Qing-Qing Zhou, Lin Dong, Ying-Chun Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2012-08-01 |
Deskripsi
The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita–Baylis–Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with good to excellent enantioselectivity (up to 94% ee) and in high yields (up to 97%).