Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase
oleh: Chloe R. Koulouris, Sian E. Gardiner, Tessa K. Harris, Karen T. Elvers, S. Mark Roe, Jason A. Gillespie, Simon E. Ward, Olivera Grubisha, Robert A. Nicholls, John R. Atack, Benjamin D. Bax
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
The catalytic mechanisms of human serine racemase reveal a ligandable pocket near Tyr121 that could be targeted for the development of novel inhibitors.