Caspase-11 signaling enhances graft-versus-host disease
oleh: Yanyan Lu, Ran Meng, Xiangyu Wang, Yajing Xu, Yiting Tang, Jianfeng Wu, Qianqian Xue, Songlin Yu, Mingwu Duan, Dongyong Shan, Qingde Wang, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Fangping Chen, Ben Lu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.