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Background and objectives: Oral mucositis is a common and debilitating complication of radiotherapy which is associated with significant morbidity. It is therefore extremely important that mucostis be prevented, or at least treated to reduce its seventy and sequelae. The objective of the study was to manage oral mucositis induced by radiotherapy and to reduce pain by using Benzydamine hydrochloride (0.15%), Chlorhexidine (0.2%) and Povidone iodine (5%) Results: Benzydamine hydrochloride is effective and delays the development of severe form of mucostis and appears more efficient in the management of radiation-induced mucosdis. Conclusions: Benzydamine hydrochloride (0.15%) is safe, well-tolerated, helps not just in delaying the progression of mucositis but also reduces the intensity of pain.