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We report the management of a 76-year-old male presenting with primary metastatic melanoma, prostatic carcinoma, and clear cell renal cell carcinoma. Each of the three cancers was identified via PSMA PET-CT, thought to be unique to prostate cancer identification. Management of this patient included axillary lymph node resection, radiation therapy, radical nephrectomy, and immunotherapy. This case emphasizes the need for a multimodal approach and a broad differential diagnosis when managing cancer patients. Furthermore, the full potential of PSMA PET-CT has yet to be established.