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Kikuchi-Fujimoto disease (KFD) or histolytic necrotizing lymphadenitis is a rare form of cervical lymphadenopathy that commonly affects young women. It is an idiopathic, self-limiting disease usually presenting with lymphadenitis, fever, and weight loss. I hereby report two cases of KFD, both of them presented with lymph node enlargements in the neck region. Excision biopsy was done after a trial of antibiotics, which gave a pathological diagnosis of KFD. KFD closely mimics, systemic lupus erythematosus and lymphoma, clinically and histologically. Although KFD is a benign disease, it has to be differentiated from these two diseases to avoid unnecessary chemotherapy, radiotherapy, and surgery.