Development of mathematical models of synthesis of the O-antigens atoxigenic strains of Vibrio cholerae based on the model of the synthesis of O-antigen secreted in the process of culturing the virulent strain of vibrio сholerae M-41 Ogawa in the production of cholera vaccine
oleh: A. V. Komissarov, O. A. Volokh, Yu. A. Aleshina, A. K. Nikiforov
| Format: | Article |
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| Diterbitkan: | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01 |
Deskripsi
The paper contains the results of the development of mathematical models for O-antigen synthesis by atoxigenic cholera vibrio strains KM 262 biovar El Tor serovar Ogawa, KM 263 biovar El Tor serovar Inaba, and M 377 O139 serogroup based on the modeling of the synthesis of O-antigen, produced in the course of cultivation of the virulent Vibrio cholerae M 41 strain belonging to classical biovar, serovar Ogawa. The data obtained provide the possibility to successfully perform the task of up-scaling the designed pilot technology for cultivation of atoxigenic cholera vibrio strains to be utilized on commercial-scale bioreactors.